SDH mutations in cancer

SDH mutations establish a hypermethylator phenotype in paraganglioma.

Paragangliomas are neuroendocrine tumors frequently associated with mutations in RET, NF1, VHL, and succinate dehydrogenase (SDHx) genes. Methylome analysis of a large paraganglioma cohort identified three stable clusters, associated with distinct clinical features and mutational status. SDHx-related tumors displayed a hypermethylator phenotype, associated with downregulation of key genes invol...

The Prevalence of P53 Mutations in Laryngeal Cancer in Kerman

Background &Aims: Laryngeal cancer is the second common cancer of respiratory tract, following the lung cancer. Carcinogenesis is a complex multistage process; molecular genetics has provided the evidence that activation of proto-oncogene and loss or inactivation of tumor suppressor genes (TSG) are involved in a large number of malignancies. One of the earliest significant tumor suppressor gene...

Genetic diagnosis of cancer: diagnosis of mutations in BRCA1 and BRCA2 in breast cancer

During the last two decays the tremendous success in molecular biology and genetics which has surprised the entire world. So that today the sequencing of whole genome has been possible for each human individual to estimate its being affected with cardiovascular and cancer diseases. However, these achievements have some important limitations and deep ethical issues which might be ignored. Geneti...

Grooming Mechanisms in SONET/SDH and Next-Generation SONET/SDH

Synchronous Optical Network (SONET) and Synchronous Digital Hierarchy (SDH) are very closely related standards, which came into being primarily as a means of transporting telephone traffic in large volumes utilizing optical fiber transmission systems. SONET was brought forth by Bellcore (Telcordia), with coordination from International Telecommunication Union (ITU) as well as other standards or...

Sdh in pdf